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KMID : 0368819960350010067
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Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 1 p.67 ~ p.76
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Changes of Plasma Growth Hormone and Homovanillic Acid Concentration after Insulin Administration in Patients with Schizophrenia
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Abstract
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The authors examined the changes of plasma level of growth hormone(GH) and homovanillic acid(HVA) after administration in schizophrenic patients and control subjects. Fifteen neuroleptics-taking patients and eight healthy control subjects
participated
in a study of insulin-induced dopaminergic perturbation, with multiple samples for plasma. HVA and GH at baseline, 60min and 90min after insulin administration. Regular insulin(0.1unit/kg) caused a significant decrease of glucose level and
increase
of
GH level after 60min in both normal controls and schizophrenic patients. We did not find significant difference of GH concentrations at baseline, 60min and 90min between normal subjects and patients with schizophrenia. In schizophrenic subjects
there
was an inverse relationship between age of onset and GH level at 90min point. The GH level of patients whose first age of onset was more then 26 years was quitely low. There appeared a bimodal distribution of GH level at 90min in schizophrenic
patients.
The clinical characteristics of the patients with higher GH level(more than 20ng/ml) were long duration of illness(more than 12 years) and old age(more than 37 years old). There was a significant difference of HVA level at baseline between normal
control subjects and schizophrenic patients. This pattern was not associated clinical variables, such as age, age of onset, duration of illness and presence of family history. Schizophrenic patients were grouped by the positive and negative
syndrome
scale. The positive group had higher HVA level at baseline than negative group. The HVA concentrations of normal control subjects and positive group decreased significantly after insulin administration, but there was no decrease in negative
group.
These
results suggest that plasma HVA concentration may be associated with the different dopaminergic alterations of heterogeneous schizophrenia. The GH and HVA level after insulin administration could be used as indices for the delineation of complex
clinical manifestations of schizophrenia.
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KEYWORD
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